Get tested with Superpower

**If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone.** Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over **100 biomarkers**, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability—all in one place.

Key benefits of Estradiol testing

• Measures your primary estrogen to assess reproductive and overall hormonal health.
• Spots imbalances that may explain irregular periods, hot flashes, or mood changes.
• Guides fertility treatment by tracking ovarian response and timing ovulation accurately.
• Clarifies causes of delayed puberty or early menopause in younger individuals.
• Protects bone and heart health by flagging low estrogen before complications arise.
• Tracks hormone therapy effectiveness to optimize dosing and symptom relief.
• Best interpreted with FSH, LH, and your menstrual cycle or symptom pattern.

What is Estradiol?

Estradiol is the most potent and biologically active form of estrogen, the primary female sex hormone. It is produced mainly in the ovaries by developing egg follicles, though smaller amounts come from fat tissue, the adrenal glands, and in men, the testes. Estradiol belongs to a family of steroid hormones made from cholesterol.

The hormone that orchestrates female reproduction

Estradiol drives the menstrual cycle, stimulates the growth of the uterine lining, and prepares the body for potential pregnancy. It also maintains bone density, supports cardiovascular health, and influences mood and cognitive function. In men, estradiol plays a quieter but important role in bone health and sperm maturation.

A window into ovarian function and hormonal balance

Measuring estradiol in blood reveals how well the ovaries are working and where someone stands in their reproductive life. Levels rise and fall throughout the menstrual cycle, drop sharply at menopause, and shift during pregnancy or with certain medications.

Why is Estradiol important?

Estradiol is the most potent form of estrogen, orchestrating reproductive function, bone density, cardiovascular health, brain chemistry, and metabolic balance in both women and men. It rises and falls across the menstrual cycle in women, peaks during reproductive years, and declines sharply at menopause. In men, it's produced in smaller amounts from testosterone and supports bone strength and libido.

It shapes fertility, mood, and bone strength

When estradiol is low—common after menopause, during breastfeeding, or with ovarian insufficiency—bones lose density faster, hot flashes and night sweats emerge, and vaginal dryness or painful intercourse may occur. Mood shifts, brain fog, and joint pain often follow. In men, very low estradiol can weaken bones and reduce sexual function.

Too much can signal hormonal imbalance or tumor activity

Elevated estradiol may point to ovarian cysts, estrogen-producing tumors, or obesity, where fat tissue converts other hormones into estrogen. Women may experience heavy or irregular periods, breast tenderness, and bloating. In men, high estradiol can cause breast tissue growth and reduced testosterone effects.

It connects reproduction, metabolism, and long-term resilience

Estradiol doesn't work alone—it interacts with progesterone, testosterone, thyroid hormones, and insulin to regulate energy, mood, and tissue repair. Chronic imbalance raises risks for osteoporosis, cardiovascular disease, and certain cancers. Tracking estradiol helps reveal how well the reproductive and metabolic systems are communicating across the lifespan.

What do my Estradiol results mean?

Low estradiol values

Low values usually reflect reduced ovarian function in premenopausal women, which occurs naturally during menopause or can result from ovarian insufficiency, hypothalamic suppression, or certain medications. In men, low estradiol may accompany low testosterone or aromatase deficiency. Common effects include reduced bone density, vaginal dryness, hot flashes, mood changes, and decreased libido in women. Men may experience joint discomfort, reduced bone health, and sometimes sexual dysfunction when estradiol drops too low.

Optimal estradiol values

Being in range suggests healthy ovarian function in premenopausal women and adequate aromatization of testosterone in men. In cycling women, estradiol fluctuates throughout the menstrual cycle, peaking just before ovulation. Optimal levels support bone mineralization, cardiovascular health, cognitive function, and reproductive tissue integrity. In men, estradiol within the reference range helps maintain bone density and lipid balance without feminizing effects.

High estradiol values

High values usually reflect ovarian hyperstimulation, estrogen-producing tumors, or exogenous hormone exposure. In men, elevated estradiol often accompanies obesity or liver dysfunction, as excess body fat and impaired hepatic clearance increase aromatase activity. Common effects include breast tenderness, fluid retention, mood swings, and menstrual irregularities in women. Men may develop gynecomastia and sexual dysfunction.

Factors affecting estradiol interpretation

Estradiol varies significantly with menstrual cycle phase, pregnancy, and menopausal status in women. Assay methodology matters, as immunoassays can be less accurate at very low levels. Medications including hormonal contraceptives, hormone replacement, and aromatase inhibitors directly influence results.