Pyridoxal 5'-Phosphate

Vitamins

Pyridoxal 5'-Phosphate

Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6 that fuels energy metabolism and neurotransmitter synthesis to support mood, cognitive function, and healthy nerve signaling. It may help ease PMS symptoms, support red blood cell formation and healthy homocysteine levels, and relieve symptoms of neuropathy.

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Key Facts

Pyridoxal 5'-phosphate (P5P) is the active, ready-to-use form of vitamin B6 that your body can immediately put to work
Supports energy metabolism, neurotransmitter production, and immune function through enzymatic reactions
More bioavailable than standard B6 forms, meaning better absorption and faster cellular availability

Ingredients

Vitamin B6 (as Pyridoxal 5'-Phosphate), Calcium Laurate, Hypromellose Capsule, Microcrystalline Cellulose, Silicon Dioxide.

Why We Chose This

Most B6 supplements require your body to convert them into P5P before they're useful — an extra metabolic step that doesn't always happen efficiently, especially as you age. This formulation skips that step entirely. Pyridoxal 5'-phosphate is the cofactor form your cells actually use for hundreds of enzymatic reactions, from breaking down amino acids to synthesizing serotonin and dopamine. Research supports P5P's superior absorption compared to standard pyridoxine, making it particularly valuable for those with absorption challenges or anyone seeking reliable B6 support for metabolic and neurological health.

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Frequently Asked Questions About Pyridoxal 5'-Phosphate

What is the supporting research for the benefits of pyridoxal 5'-phosphate?

Higher plasma PLP is associated with better postprandial glucose responses. (critical-illness study)
High-dose PLP appears to reduce abnormal movements in tardive dyskinesia. (tardive dyskinesia trial)
Adequate vitamin B6 status appears critical for normal nervous system function. (PNPO/PLP mechanistic study)

How do I take pyridoxal 5'-phosphate?

Take 1 capsule daily with food, or follow your healthcare provider's guidance for your specific needs.

The active form skips conversion steps, so your body absorbs and uses it immediately for energy and neurotransmitter production.

Can I take pyridoxal 5'-phosphate with other supplements or medications?

Check with your doctor before combining pyridoxal 5'-phosphate with medications, as certain drugs like levodopa, barbiturates, and anticonvulsants may interact. Most supplement combinations are generally safe when taken at appropriate doses.

Who might benefit from taking pyridoxal 5'-phosphate?

People with kidney disease, autoimmune conditions like rheumatoid arthritis, or alcohol dependence often have low B6 levels and may benefit from supplementation. Pregnant women experiencing morning sickness and those taking certain medications like antiepileptic drugs are also candidates for P5P support.

How long does it typically take to notice effects of pyridoxal 5'-phosphate?

Most people notice effects within one to three weeks of consistent daily use, though this timeline depends on your baseline B6 status. Since your body excretes this water-soluble vitamin within 24 hours, regular supplementation is key to building and maintaining benefits.

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