Key Facts

• Methyl-Guard Plus delivers bioactive methyl donors — compounds that support cellular processes requiring methyl group transfer, a fundamental mechanism in energy production, DNA synthesis, and neurotransmitter regulation
• The formula combines trimethylglycine (betaine), 5-methyltetrahydrofolate (5-MTHF), and methylcobalamin — three forms already in their active, body-ready state — with supporting B vitamins for efficient methylation pathways
• Supports whole-body methylation, the biochemical process underlying cardiovascular, cognitive, and mood-related functions

Ingredients

Riboflavin (as Riboflavin-5-Phosphate Sodium), Vitamin B6 (as Pyridoxal-5-Phosphate), Folate (as L-5-Methyltetrahydrofolate), Vitamin B12 (as Methylcobalamin), Betaine Anhydrous (Trimethylglycine), Hypromellose capsule, Calcium Citrate, Calcium Laurate.

Why We Chose This

Methylation — the transfer of methyl groups across thousands of cellular reactions — underpins energy metabolism, cardiovascular health, and brain function. Many people struggle to maintain optimal methylation capacity due to genetics, diet, or age-related changes. Methyl-Guard Plus stands out because it uses pre-activated forms of folate, B12, and betaine that bypass conversion steps, making them immediately available for methylation reactions. Research shows this combination effectively supports homocysteine metabolism and cellular methylation capacity, addressing a gap that standard B vitamins alone may not fill.