Berberine

Botanical Supplements

Berberine

Berberine is a natural plant compound that supports healthy blood sugar and cholesterol levels while promoting metabolic function. It may also help with weight management and gut and cardiovascular health.

Learn more about Berberine

Cancel anytime

HSA/FSA eligible

Results in a week

Physician reviewed

Every result is checked

CLIA-certified labs

Federal standard for testing

HIPAA compliant

Your data is 100% secure

All biomarkers

Content

Main Heading
Sub Heading
Sub Sub Heading

Key Facts

Berberine is a plant alkaloid compound traditionally used in Ayurvedic and Chinese medicine, now studied extensively for metabolic support
Supports healthy blood sugar metabolism, insulin sensitivity, and cholesterol levels by activating cellular energy pathways
This formulation combines berberine HCl with berberine phytosome — a phospholipid-enhanced form that improves absorption and reduces GI irritation

Ingredients

Berberine HCl (from Indian Barberry extract, root) 450 mg, berberine phytosome (Berberis aristata extract, root with phospholipid complex from pea, sunflower, and grape seed) 550 mg. Grape seed extract in the phytosome matrix protects the gastrointestinal tract from potential irritation.

Why We Chose This

Berberine addresses a real gap: many people struggle with metabolic resilience — maintaining steady blood sugar and healthy cholesterol without pharmaceutical intervention. This formulation stands out because it pairs the most clinically studied form (berberine HCl) with a phytosome delivery system that enhances absorption while minimizing digestive upset. Research supports berberine's role in activating AMPK, an enzyme that helps cells use glucose more efficiently. The addition of grape seed extract offers GI protection, making this a thoughtfully designed option for anyone seeking metabolic support grounded in both traditional use and modern science.

Other Botanical Supplements

See more supplements

Curcumin Phytosome - 60 Servings

Curcumin Phytosome — 60 servings is a highly bioavailable curcumin supplement formulated for enhanced absorption. It may help support a healthy inflammatory response, reduce occasional joint stiffness and exercise-related soreness, and provide antioxidant support for overall wellness.

Learn more

Rhodiola

Rhodiola is a natural adaptogen that helps the body manage stress while boosting energy, mental focus, and stamina; it may help reduce fatigue, support mood balance, and improve cognitive performance under pressure.

Learn more

Frequently Asked Questions About Berberine

What is the supporting research for the benefits of berberine?

Berberine is associated with glucose and HbA1c reductions comparable to metformin. (type 2 diabetes clinical trial)
Meta-analyses show berberine significantly reduces fasting glucose and HbA1c. (systematic review and meta-analysis)
A berberine formulation is associated with improved glycemic markers in prediabetes. (prediabetes RCT)

How do I take berberine?

Take 1-2 capsules twice daily with food, or as recommended by your healthcare practitioner.

Consistent daily use supports your body's metabolic and cardiovascular function over time.

Can I take berberine with other supplements or medications?

Berberine can interact with certain medications — particularly those processed through the same liver enzymes (CYP2D6, CYP2C9, CYP3A4) — so check with your healthcare provider before combining it with prescriptions. For supplements, there's limited interaction data, but your doctor can help determine what's safe to take together.

Who might benefit from taking berberine?

People managing blood sugar levels, cholesterol, or weight benefit from berberine's metabolic support. Women with PCOS and those seeking gut health optimization also find it valuable.

How long does it typically take to notice effects of berberine?

Most people notice early changes in fasting glucose within one to four weeks, with more measurable improvements in blood sugar and cholesterol by eight to twelve weeks. Consistent use over at least eight weeks, paired with diet and exercise, typically yields the most noticeable results.

How it works

Test your whole body

Get a comprehensive blood draw at one of our 3,000+ partner labs or from the comfort of your own home.

An Actionable Plan

Easy to understand results & a clear action plan with tailored recommendations on diet, lifestyle changes, supplements and pharmaceuticals.

A Connected Ecosystem

You can book additional diagnostics, buy curated supplements for 20% off & pharmaceuticals within your Superpower dashboard.

Superpower is changing thousands of lives

90.2k, Alo wellness club trainer

Superpower tests more than  100+ biomarkers & common symptoms

Re-balance hormones

Say goodbye to fatigue

“Turns out my chronic fatigue was from hormone imbalance. Not a single doctor could tell me that while Superpower caught it immediately. Now I’m taking action and supplements and have never felt better.”

Mariah Wilkinson

Increase free testosterone

‍Finally gain muscle

"For years I was gymming but not seeing results. My energy was low, recovery was slow, and no one could knew why. Superpower showed me my testosterone was out of range. With the right plan, I finally broke through”

James Bromley

Man in a white cap standing shirtless outdoors, looking to the side under a clear blue sky.

Manage aches

Manage inflammation response

"I didn’t realize fatigue and aches were signs of chronic inflammation.
Superpower caught the imbalance before it became more of a problem”

A person looking to the side with a focused expression against a plain background.

Amara Gupta

A person wearing a white tank top jogs on a paved road.

Reduce cortisol

Stress less and feel more energy

"I always thought my tiredness was just part of a busy life. Superpower showed me my cortisol was out of balance. With a few changes, I finally feel energized again."

Conway Simons

Improve gut microbiome

Debloat and  feel lighter

"I used to feel constantly bloated and sluggish after meals. No one connected it to my gut health. With the right plan, my digestion is smoother, and I finally feel light and comfortable again."