Method: Shotgun metagenomic sequencing (CLIA 21D2062464); not cleared or approved by the FDA. Results reflect relative microbial abundance for wellness education purposes. Not intended to diagnose or treat disease and not a substitute for clinical consultation. Microbial associations are based on emerging scientific research and may change over time. Derived from laboratory results. This score or index is not an FDA-cleared test. It aids clinician-directed assessment and is not a stand-alone diagnosis.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Trimethylamine testing
- TMA/TMAO precursor production capacity tracking
- cardiovascular metabolite risk assessment
What is Trimethylamine?
This metric estimates your gut microbiome's functional capacity to produce trimethylamine (TMA) from dietary choline, carnitine, and betaine. TMA is absorbed and converted by the liver to trimethylamine N-oxide (TMAO), which has been studied for associations with cardiovascular risk. Derived from relevant enzyme gene abundance.
Why is Trimethylamine important?
Gut-produced TMAO is one of the more studied microbiome-cardiovascular connections. Elevated TMAO has been associated with cardiovascular risk markers in research, including studies published in peer-reviewed cardiovascular and nutrition journals. TMA production capacity reflects the abundance of TMA-lyase-encoding bacteria. High red meat and egg intake alongside high TMA production capacity may amplify TMAO generation.
What insights will I get?
Your TMA production capacity may indicate how readily your gut microbiome converts dietary choline and carnitine to TMA - and ultimately to TMAO. This metric may be particularly relevant for members with cardiovascular health goals or high red meat and egg dietary patterns.
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